Today, we stand on the brink of the fourth industrial revolution which fuses the physical, digital and biological spheres of technology that will fundamentally alter the way we all treat our health, eat sustainable and live better. This revolution which is being built by hundreds of startups around the world will have a biological base.

IndieBio is pleased to announce the latest 15 IndieBio companies based here in San Francisco. Based in SF, they all have a global vision, hailing from all corners of the globe to change humanity through a blend of technology and biology. In alphabetic order:

Amaryllis Nucleics

Amaryllis empowers researchers by accelerating important discoveries in genomics. Our technology halves the time and reduces the cost of RNA sequencing by 8-fold to empower the cutting edge cancer diagnostics, pharmaceutical development, and food security innovations.

Ardra

Natural and petroleum free products are the fastest growing category in cosmetics, worth over $23B globally. Ardra is engineering technologies to produce completely petroleum-free, high purity, and sustainable biochemicals for the cosmetics market, as well as for pharmaceuticals and foods.

AstRoNA

Food poisoning is a serious global concern today with over 1 in 6 people getting food poisoning resulting in over 128,000 hospitalizations in just the US every year. AstRoNA Biotechnologies is engineering a simple to use detector that can be deployed on-site at every phase of food production from field to table. Our technology can screen all food types in under an hour versus today’s 48 hour standard food safety process.

BioNascent

BioNascent is determined to close the gap between the health outcomes of breastfed and formula fed infants. To do so, we manufacture the world’s first humanized infant formula aimed at delivering a perfect balance of essential amino acids and carbohydrates.

Endura Bio

Twenty five percent of the world’s arable land is currently unusable due salt groundwater contamination and more arid environments. Endura Bio is engineering salt and drought tolerant plants to be more salt and drought tolerant to increase yields from marginal lands globally, unlocking the potential to feed the world.

Genome Surveillance

DNA sequencing is driving the new genomic revolution but it’s currently bottlenecked with high compute costs and inaccuracies. Genome Surveillance is revolutionizing DNA sequencing to make it ten times faster and more accurate through reducing the heavy computational load and dropping it to a fraction of the cost of current technologies.

Jungla

Today we only understand what ~0.5% of the genetic variants in patient genomes mean and it impedes our ability to diagnose and treat genetics diseases and risk factors. At Jungla, we have developed a software platform that can accurately model the impacts of mutations and accelerate diagnostic development by 5x by harnessing advanced statistical algorithms that were developed at the leading Stanford bioinformatics lab.

Knox

Knox Medical Diagnostics is bringing hospital level asthma management technology to families at home with the first tool to revolutionize decades old practices. Like a blood sugar monitor for diabetes, this tool provides predictive insights to parents of asthmatics that will prevent asthma attacks, enable proactive medication management, and give patients and parents peace of mind.

mFluidX

Zika Virus, Dengue Fever, and other global pandemics ravish countries as a result of a lack of rapidly deployable field based diagnostics. mFluidX has created a DNA diagnostic test the size of a stick of gum that can be deployed and provide results in 30 minutes. All with a self-powered disposable chip that costs 1000x less than current bulky benchtop based lab diagnostics.

MiraculeX

MiraculeX is creating the next generation of the best tasting and healthy sweeteners in the world using plant proteins under one calorie per serving. We get rid of the sugar and terrible aftertaste of your everyday sweeteners.

MycoWorks

MycoWorks is building a world with fewer plastics, no toxins, and zero waste by harnessing the power of Mushrooms. We grow natural alternatives to plastic foams, textiles, and leather, for use in aerospace, automobiles, apparel, and architectural interiors.

OneSkin

Safety testing for cosmetics today relies on inaccurate and inhumane animal testing. OneSkin is developing a human 3D skin tissue model to do toxicity tests that are more accurate, reliable, and completely animal free that can provide a deeper understanding of human skin.

Qidni

Over one million people globally die of untreated kidney failure each year. In addition, dialysis technology has stagnated over the last fifty years with virtually no progress. Qidni Labs is building an implantable artificial kidney for 10% of patients with kidney disease, many of which get kidney failure. Our device is estimated to last the equivalent amount of time as a transplanted kidney without needing maintenance or cleaning.

SyntheX

SyntheX is expanding drug design into the ‘undruggable’ space for the treatment of cancer and rare diseases. We implement an innovative platform for the accelerated discovery of new classes of therapeutics that target the Achilles’ heel of cancer cells in a highly specific and selective manner.

Willow Cup

Willow Cup is optimizing plant-based proteins to create healthy animal-free options for premium indulgences, starting with specialty tea and coffee. We are hacking the infinite properties of plant proteins to replace traditional dairy for a more sustainable future.

Biology is Technology.