Full Time / San Francisco/Los Angeles
Diadem Biotherapeutics Inc., is a part of IndieBio’s current accelerator cohort. We are seeking a Cell & Molecular Biologist with genome engineering expertise to join a cross-disciplinary team developing novel, immunotherapeutic biologics for chronic inflammation and autoimmune diseases. The position will be part of a dynamic group responsible for developing a platform for rapidly prototyping a novel class of biologics. The ideal candidate is a detail-oriented, team-player who can prioritize responsibilities, multi-task and remain flexible with changing needs and evolving responsibilities in a start-up environment. The candidate would have the opportunity to participate in community activities and biotech business development curriculum at the IndieBio accelerator/incubator in San Francisco. The ideal candidate is willing to relocate to Diadem’s Los Angeles headquarters in early 2020. The position title and compensation level will be commensurate with the candidate’s qualifications and experience.
Responsibilities and Duties
- Design and execute efficient genome engineering technologies for primary cells.
- Characterize and QC engineered primary cells and cell lines.
- Purify and characterize cell-derived biologics.
- Develop cell-based functional assays, analytical test methods, and new analytical technologies for biologics testing.
- Write technical reports, protocols, and SOPs.
- Maintain accurate laboratory notebook and relevant documentation.
- Prepare study reports and presentations for group meetings, conferences, publications and regulatory filings.
- Present results in both internal and external forums.
- Participate with and/or direct Industry and Academic collaborators to support R&D.
Qualifications and Skills
- Ph.D. in a relevant field or M.S. + Industry experience.
- Demonstrated track record of scientific research achievement, creativity, and independent critical thinking, as shown by a strong publication or patent record and/or significant contributions to a therapeutic development program.
- Experience with mammalian genome editing techniques (CRISPR/Cas9, Recombinase mediated engineering, transfection, electroporation, and viral transduction).
- Ability to perform and analyze quantitative immuno-assays including Western Blots, and ELISAs or Luminex Panels.
- Ability to develop and perform complex cell-based functional assays.
- Statistical data analysis and/or bioinformatics analysis.
- Strong oral presentation and communication skills.
- Organized, collaborative, team-player attitude.
- Cell characterization by flow cytometry a plus.