Introducing IndieBio NY Class 2

INDIEBIO NY class two MEET INDIEBIO SF CLASS 11 CONTACT FOR AN EARLY INTRODUCTION

Slide "If we could address diseases of the mouth in a more precise way, we would have less downstream systemic problems."
Brickbuilt

Therapeutics
Using microbiome-derived LBPs to target oral disease

Brian Klein, CEO

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Slide Oral diseases are systemic diseases suffered by over 3.5 billion people world wide: the periodontal disease suffered by half of American adults is linked to diseases such as heart disease, stroke, diabetes and obesity.

BrickBuilt Therapeutics is developing a live biological product discovered by CEO Brian Klein during his graduate thesis research. Brickbuilt is using this strain and others in its microbial library to develop microbiome-focused therapeutics for oral and systemic diseases.

This is not a single asset company; BrickBuilt scientists have built a platform to screen their own salivary libraries to identify bacterial stains which have therapeutic merit. MORE
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Slide "One third of the food that you eat is dependent on pollinators. Cotton is pollinated by bees. A lot of the animals that we eat feed on the plants that bees pollinate. A world without bees is definitely going to sting."

Pesticide protection for bees

James Webb, CEO

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Beemmunity
Slide One-third of food is pollinator dependent, which means simply: pollinator survival is human survival. Moreover, bees pollinate the plants that support human life by pollinating the plants that feed our livestock and compose our textiles.

Beemmunity’s product makes bees immune to the toxic effects of pesticides and leads to 80% survival when bees are dosed with lethal concentrations of pesticide.

Moreover, Beemmunity improves bee immunity to verroa mites, scourge of beekeepers and killer of hives, by minimizing sublethal pesticide exposure. MORE
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Slide "Wouldn't it be awesome to live in a world where people can have the newest clothes every six months if they want, but they're able to be disposed of: treated, returned and recycled or upcycled or broken down into their components and put into things like garden and compost." Bucha
Leather
Harnessing microbial nanocellulose and green chemistry to create high-quality leather substitutes

Zimri Hinshaw, CEO

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Slide Leather’s durability keeps it in demand, to the tune of over 4 million tons of solid waste each year; synthetic leathers made from petrochemicals are not an eco-friendly solution. Bucha Leather creates a novel biomaterial starting with infinitely renewable bacterial nanocellulose, one of the fundamental building blocks of nature.

Bucha Leather biomaterial products are produced in weeks, rather than months or years of competitor goods. Materials are processed with designer finishes such as natural dyes and waxes to create a comparable customer experience while maintaining a sustainable end-of-life. Bucha Leather is a sustainable answer to the animal and plastic leather industry. MORE
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Slide "The true empowerment comes from the ability to tell Mom what's in her breast at any given moment. Give Mom an ingredient deck for the boob." Free
to
Feed
Empowering nursing mothers to navigate infant food intolerance

Trill Paullin, CEO

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Slide Free to Feed CEO Trill Paullin experienced infant allergy trauma when she discovered bloody stool in her daughter’s diaper. The reaction was due to an unknown allergen in her breast milk, which required a year-long severe elimination diet to continue breastfeeding. She is not alone: one out of every four infants will experience a food allergy, a number that has tripled in the past two decades.

Using her molecular biology training, Paullin recognized that identifying specific peptides present in breast milk would allow mothers of allergic infants to safely continue breastfeeding. Free to Feed has identified the immunogenic peptides that cause the infant allergic responses and is generating monoclonal antibodies to these peptides to create a dipstick allergen test. MORE
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Slide "Cow's milk as a source of nutrition is species specific. So why do we give cow's milk for human babies in baby formula?"
Harmony
Baby
Nutrition
Producing animal-free, allergy-free, and environmentally-friendly breast milk protein-based formula

Wendel Afonso, CEO

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Slide One in six babies suffer allergies to formula, leading to painful cries and sleepless nights for mother and infant alike. Alternatives such as soy-based formula or hydrolyzed cow’s milk formula are expensive and can also have violent side effects like diarrhea and vomiting.

Harmony Baby Nutrition is a food science-based company that uses precision fermentation to produce human breast milk proteins and create infant formulas that most closely mirror human breast milk. Harmony offers the only dairy-free, allergy-free, and environmentally friendly baby formula in the world.

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Slide "What if we could take toxic nitrogen and phosphorus from the water and put it back back in the land or, even better, produce something that we can use to feed the world?" microTERRA Growing closed-loop, sustainably grown plant protein

Marissa Cuevas, CEO

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Slide Protein production places a high cost on land and water resources: the global demand for protein means a gap in protein demand totaling 57 billion USD by 2026.

This woman-led startup has created a scalable, sustainable and affordable plant-based protein ingredient by growing water lentil in fish farm wastewater, transforming fish waste into a superfood rich in antioxidants, calcium, iron, fibre, vitamins & plant proteins.

The beauty of the process is that the more water utilised by lentils, the more water cleaned, benefiting both people and planet. This company is at the forefront of the circular economy, using a unique business model that supports fish farmers and delivers superfood to the consumer. MORE
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Slide "Eventually, the glow stick plastic is disrupted, their chemicals enter our environment, and we're just left with the after effects. They're actually these little time bombs. " Nyoka
Design
Labs
Replacing toxic chemical glow sticks with the power of bioluminescence

Paige Whitehead, CEO

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Slide There is a $4 billion USD lighting industry for glow sticks that reaches beyond the 1 million disposable glow sticks used recreationally each year: industrial sectors such as open-ocean fishing and humanitarian requirements such as search-and-rescue parties also rely on single-use light sources. Nyoka Design Labs is using biological light to increase sustainability across this industry.

Their first product is a totally compostable Chemiluminescence glow stick (the “Lümi”) already on the market with $1,300 sales/month.

Nyoka is using directed evolution on natural enzymes to increase brightness and duration of biological light; they are developing a Bioluminescence glow stick that will meet the highest specifications required by NATO, a potential early customer. This path mirrors the path of harsh chemicals used in today’s disposable glow sticks, which were inefficient when first developed. MORE
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Slide "Skin health isn't nature or nurture—it's both. Genetics testing provides insight into our predisposition, or natured self, and microbiome testing provides insight to our environment, or nurtured self."
Sequential
Skin
Tailoring skin health through genetics and microbiome tests

Oliver Worsley, CEO

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Slide Consumers around the world are demanding a more personalized experience. Surveys show that 80% of consumers will choose and spend more on brands that personalize their experience, but brands who fail to execute well lose value.

Sequential Skin has created the world’s first science-backed skin health kit, combining the analytical power of human and microbial genetics to help consumers make healthy choices. The Sequential Skin kit uses advanced genetic sequencing technology to understand how genes across the skin microbiome, and the environment, interact to create an individual's unique skin needs.

Sequential Skin boosts the customer’s overall health by providing the exact ingredients and products that will work best for each individual’s skin. The founders plan to branch into precision medicine as a secondary application after their successful consumer launch. MORE
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Slide "We're making small reactors that can be scaled infinitely. When cell culture is scaled in the way that we're pursuing, therapies are developed faster." Stembionix Stem Cell marketplace

Ethan Stillman, CEO

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Slide More than 3,000 clinical trials using stem cell therapies have been registered with the WHO, but access to stem cell technologies and the forthcoming personalized tissue growth breakthroughs remains difficult.

Stembionix is building bioreactors to automate the culture and design of cells, tissues, and organ systems, and to facilitate the distribution of these biological materials. Stembionix is creating a future where everyone has access to on-demand personalized tissue culture and tissue-derived therapeutics.

The go-to-market product is a Personal Stem Cells service which is enabled by our mailable bioreactor system and accompanying online cell management platform. With Stembionix’s Personal Stem Cells service, you can access, store, and use your own stem cells, and explore the uniqueness of your personal biology.

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Slide "By discarding plastics after a single use, all the capital put in to extract and manufacture the plastic is lost. If we can find a way to turn that plastic into something useful, we're closing the loop in the circular economy of plastics." Scindo Engineering novel enzymes to degrade vinyl plastics.

Gustaf Hemberg, CEO

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Slide Plastics are crucial materials in today's industrial society, but the properties that make them so useful cause a heavy burden on the environment. Over 9 billion tons of plastic have been manufactured; 79% ends up in landfill to degrade over long periods of time. Additionally, these landfill plastics are continuously leaching harmful toxins and greenhouse gases into the environment.

Put another way: 8 Million tons of plastic ends up in the oceans every year. This is the equivalent of one truck unloading every minute. The biggest offender are the unrecyclable plastics (PE, PVC, PP, PS) which lack natural cleavage sites hindering natural recycling.

Scindo has engineered a platform of proprietary enzymes capable of breaking down polymers that lack natural cleavage points. MORE
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